Diabetes developments
Pain relief under development could help millions worldwideScientists could be one step closer to developing a unique painkiller for
millions of people worldwide with diabetes, who currently have little in the way
of effective treatments for the severe chronic pain associated with the disease
(diabetic neuropathic pain).
The Wellcome Trust has awarded £3.8 million to a team of researchers led by
David Wynick, Professor of Molecular Medicine at the University of Bristol, to
develop a new analgesic drug based on the protein galanin. Prof Wynick will be
working with the UK contract drug discovery company BioFocus and the University
spin-out company NeuroTargets.
The award, under the Wellcome Trust's Seeding Drug Discovery initiative, follows
a smaller award of £540,000 to fund early stage research and takes the total
support for this project to £4.3 million.
Galanin is a small protein made by the pain sensing cells and its levels greatly
increase after injury or damage to these nerves. After 10 years investigating
its function, Prof Wynick and his colleague Dr Fiona Holmes have shown that
galanin reduces neuropathic pain in a number of models of disease. Research into
the use of galanin for multiple sclerosis and Alzheimer's disease has also had
positive initial results.
"A drug that mimics the effects of galanin could offer relief to the millions of
people with diabetes worldwide that currently suffer from this debilitating
pain. At present we know of no other pharmaceutical company that is exploring
galanin to develop a pain treatment and we are delighted that The Wellcome Trust
is supporting our work in this area," said Prof Wynick.
Rick Davis of the Wellcome Trust commented: "Existing painkillers can prove
largely ineffective against neuropathic pain so we are pleased to support this
project, which addresses an area of huge unmet clinical need."
Diabetes is the commonest cause of neuropathic pain which is often experienced
as a burning or electrical pain and to date existing painkillers have proved
largely ineffective. Latest estimates by the World Diabetes Foundation predict
that the world's population of diabetes sufferers will jump from 285 million in
2010 to 438 million by 2030 given the increasing levels of obesity, and in the
UK about 5% of the population currently have diabetes. Of those with diabetes,
over half will develop peripheral nerve damage (neuropathy) and 15-20% of those
patients will develop chronic neuropathic pain, indicating the potentially huge
market for a more effective painkiller.
It should take about three years to develop a drug suitable for testing in human
trials and if those studies were successful then at least another eight years
before the drug was commercially available.
